Question

I am a breastfeeding mother and i want to know if it is safe to use NSC 46078? Is NSC 46078 safe for nursing mother and child? Does NSC 46078 extracts into breast milk? Does NSC 46078 has any long term or short term side effects on infants? Can NSC 46078 influence milk supply or can NSC 46078 decrease milk supply in lactating mothers?

NSC 46078 lactation summary

NSC 46078 is unsafe in breastfeeding
  • DrLact safety Score for NSC 46078 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of NSC 46078 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that NSC 46078 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using NSC 46078 .
  • It is recommended to evaluate the advantage of not breastfeeding while using NSC 46078 Vs not using NSC 46078 And continue breastfeeding.
  • While using NSC 46078 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NSC 46078 usage in lactation

Metabolite of chlorazepate, diazepam, pinazepam y prazepam. It metabolizes to oxazepam. Eventual and low dose use of benzodiacepines are compatible with breastfeeding. Use the short-acting benzodiazepine and minimal effective dose as possible mostly in the neonatal period. Follow-up for sedation and feeding ability of the infant. Bed-sharing is not recommended for mothers who are taking this medication.

Alternate Drugs for Anxiolytics. ATC N05B

Alprazolam(Low Risk)
Clorazepate(Low Risk)
Diazepam(Low Risk)
Lorazepam(Safe)
Oxazepam(Safe)
Meprobamate(Low Risk)
Clobazam(Low Risk)
Bentazepam(Low Risk)
Bromazepam(Unsafe)
Buspirone-Hcl(Low Risk)
Clotiazepam(Low Risk)
Halazepam(Low Risk)
Ketazolam(Unsafe)
Medazepam(Unsafe)
Pinazepam(Unsafe)
Prazepam(Unsafe)
Tetrazepam(Unsafe)
Mexazolam(Unsafe)
Nordiazepam(Unsafe)
Miltown(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.