Is Captopril Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Captopril? Is Captopril safe for nursing mother and child? Does Captopril extracts into breast milk? Does Captopril has any long term or short term side effects on infants? Can Captopril influence milk supply or can Captopril decrease milk supply in lactating mothers?

Excreted into breast milk in non-significant amount without harm effects observed among breastfed infants of mothers treated with Captopril. The American Academy of Pediatrics rates it as usually compatible with Breastfeeding.

Because of the low levels of captopril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

In one report of 12 mothers, several continued to breastfeed their infants while taking captopril 100 mg three times daily. No adverse effects were seen in the infants.[1]

In a series of controlled studies reported in one paper, captopril had no effect on the circadian rhythm of prolactin, the response to prolactin-stimulating drugs or serum prolactin in patients with prolactin-secreting tumors.[3]In a study of young hypertensive males, captopril 25 mg orally markedly decreased serum prolactin at 90 minutes after the dose compared to placebo.[4] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.In one report, 1 woman out of 12 subjects was unable to produce enough milk for the study while taking captopril 100 mg 3 times daily even though she had been successfully breastfeeding for 6 months.[1] It is not known if this decrease was an effect of captopril.