Is N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate? Is N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate safe for nursing mother and child? Does N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate extracts into breast milk? Does N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate has any long term or short term side effects on infants? Can N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate influence milk supply or can N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate decrease milk supply in lactating mothers?
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate lactation summary
- DrLact safety Score for N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate usage in lactation
Although it is concentrated in the milk, the theoretical dose ingested by the infant does not reach 6% of the therapeutic dose (Wagner 1990, McQuinn 1990), even with a maternal dose as high as 200 mg daily. American Academy of Pediatrics: medication usually compatible with breastfeeding.
Answer by DrLact: About N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate usage in lactation
Limited information indicates that maternal doses of flecainide up to 200 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Because of the relative lack of data concerning breastfeeding during maternal flecainide therapy, exclusively breastfed infants should be carefully monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.
Alternate Drugs for Anti-arrhythmics class I and III
Amiodarone(Unsafe)
Disopyramide(Safe)
Flecainide(Safe)
Mexiletine(Safe)
Procainamide(Safe)
Propafenone(Low Risk)
Quinidine(Safe)
Lidocaine(Safe)
Encainide-Hcl(Low Risk)
Flecainide Acetate(Safe)
Lignocaine(Safe)
Amiodarone Hydrochloride(Unsafe)
Procainamida(Safe)
Propafenona(Low Risk)