Is Propranolol Hydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Propranolol Hydrochloride? Is Propranolol Hydrochloride safe for nursing mother and child? Does Propranolol Hydrochloride extracts into breast milk? Does Propranolol Hydrochloride has any long term or short term side effects on infants? Can Propranolol Hydrochloride influence milk supply or can Propranolol Hydrochloride decrease milk supply in lactating mothers?
Propranolol Hydrochloride lactation summary
- DrLact safety Score for Propranolol Hydrochloride is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Propranolol Hydrochloride is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Propranolol Hydrochloride does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Propranolol Hydrochloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Propranolol Hydrochloride usage in lactation
Excreted into breast milk in no significant levels and without side-effects observed in breastfed infants from treated mothers.
Answer by DrLact: About Propranolol Hydrochloride usage in lactation
Because of the low levels of propranolol in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. Studies during breastfeeding have found no adverse reactions in breastfed infants clearly attributable to propranolol. No special precautions are required. Propranolol has been used successfully in cases of persistent pain of the breast during breastfeeding.[1]
Propranolol Hydrochloride Side Effects in Breastfeeding
A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. Of 8 mothers taking propranolol, one reported sleepiness in her breastfed infant, but she was also taking other unspecified drugs for hypertension.[12] A case of bradycardia in a 2-day-old breastfed infant was reported to the French pharmacovigilance system. However it is not clear from the report whether the mother had been taking propranolol near term and might have transmitted the drug to the infant transplacentally.[13]
Propranolol Hydrochloride Possible Effects in Breastfeeding
Relevant published information on the effects of beta-blockade or propranolol during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[14]
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