Is Vorikonazole Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Vorikonazole? Is Vorikonazole safe for nursing mother and child? Does Vorikonazole extracts into breast milk? Does Vorikonazole has any long term or short term side effects on infants? Can Vorikonazole influence milk supply or can Vorikonazole decrease milk supply in lactating mothers?
Vorikonazole lactation summary
- DrLact safety Score for Vorikonazole is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Vorikonazole may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Vorikonazole may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Vorikonazole low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Vorikonazole We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Vorikonazole usage in lactation
Antifungal drug with similar structure than fluconazole available for systemic, oral and intravenous use, and topically for ophthalmic purposes. A latest update no published data on excretion in breast milk were found. Pharmacokinetic data indicates that it may likely pass into the milk in amounts that could be significant.Authorized use in children as young as 2 years of age. It has been used in 10-months-old infants. Until more published data on this drug regarding breastfeeding is available, safer alternatives of better known drugs, should be preferable, especially during the neonatal period and in case of prematurity. The small dose and poor absorption into plasma of most ophthalmic preparations makes it unlikely the pass of the drug into breast milk in significant amount.
Alternate Drugs for Antimycotics for systemic use
Fluconazole(Safe)
Ketoconazole(Safe)
Amphotericin B(Low Risk)
Terbinafine(Safe)
Itraconazole(Safe)
Caspofungine Acetate(Low Risk)
Flucytosine(Unsafe)
Griseofulvin(Safe)
Voriconazole(Low Risk)
Anidulafungin(Low Risk)
Oriconazole(Safe)