Is UNII-B321AL142J Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-B321AL142J? Is UNII-B321AL142J safe for nursing mother and child? Does UNII-B321AL142J extracts into breast milk? Does UNII-B321AL142J has any long term or short term side effects on infants? Can UNII-B321AL142J influence milk supply or can UNII-B321AL142J decrease milk supply in lactating mothers?
UNII-B321AL142J lactation summary
- DrLact safety Score for UNII-B321AL142J is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of UNII-B321AL142J may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that UNII-B321AL142J may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of UNII-B321AL142J low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using UNII-B321AL142J We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-B321AL142J usage in lactation
INon-glycosylated stimulating factor of granulocyte colonies (G-CSF) which is obtained by recombinant technology. It is practically identical to the naturally occurring product that is found in the breast milk.It is indicated for the treatment of cancer-related neutropenia, and autologous bone marrow transplantation. At last update no published data on excretion in breast milk were found. A high molecular weight makes unlikely its excretion into breastmilk in a significant amount.Its low oral bioavailability hampers absorption into infant plasma from the breast milk ingested, as for their proteic nature it is degraded in the gastrointestinal tract, not being absorbed. Other substances similar in composition and action as Filgrastim and Lenograstim are excreted into breast milk in trace amounts and have been used to treat sepsis and necrotizing enterocolitis in newborn and premature without harmful effects in the infants. Until more data about this drug regarding breastfeeding is obtained, alternatives that are known to be safer should be preferable, especially during the neonatal period and/or in case of prematurity.
Alternate Drugs for Immunostimulants. Citokines and Immunomodulators. ATC L03
Glatiramer(Low Risk)
Filgrastim(Safe)
Glatiramer Acetate(Low Risk)
Interferon Beta-1a(Safe)
Interferon Beta-1b(Safe)
Lenograstim(Safe)
Molgramostim(Low Risk)
Interferon alfa-n1(Safe)