Is 1-Isopropyl-5-(4-chlorophenyl)biguanide Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 1-Isopropyl-5-(4-chlorophenyl)biguanide? Is 1-Isopropyl-5-(4-chlorophenyl)biguanide safe for nursing mother and child? Does 1-Isopropyl-5-(4-chlorophenyl)biguanide extracts into breast milk? Does 1-Isopropyl-5-(4-chlorophenyl)biguanide has any long term or short term side effects on infants? Can 1-Isopropyl-5-(4-chlorophenyl)biguanide influence milk supply or can 1-Isopropyl-5-(4-chlorophenyl)biguanide decrease milk supply in lactating mothers?
1-Isopropyl-5-(4-chlorophenyl)biguanide lactation summary
- DrLact safety Score for 1-Isopropyl-5-(4-chlorophenyl)biguanide is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 1-Isopropyl-5-(4-chlorophenyl)biguanide is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 1-Isopropyl-5-(4-chlorophenyl)biguanide does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 1-Isopropyl-5-(4-chlorophenyl)biguanide safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 1-Isopropyl-5-(4-chlorophenyl)biguanide usage in lactation
It is an anti-malaria compound that combines 1-Isopropyl-5-(4-chlorophenyl)biguanide with Atovacuona. 1-Isopropyl-5-(4-chlorophenyl)biguanide is considered to be an essential drug and compatible with BF by WHO.
Alternate Drugs for Antimalarials. ATC P01B
Chloroquine(Safe)
Hydroxychloroquine(Safe)
Mefloquine(Safe)
Pyrimethamine(Safe)
Quinine(Safe)
Atovaquone(Low Risk)
Primaquine(Low Risk)
Artemisinin(Safe)
Halofantrine-HCl(Unsafe)
Lumefantrine(Safe)
Primaquine Phosphate(Low Risk)
Proguanil(Safe)
Sulfadoxine(Low Risk)
Sulphormethoxine(Low Risk)
Quinine Sulfate(Safe)