Question

I am a breastfeeding mother and i want to know if it is safe to use Tc 99m hexakis-methoxyisobutylisonitrile? Is Tc 99m hexakis-methoxyisobutylisonitrile safe for nursing mother and child? Does Tc 99m hexakis-methoxyisobutylisonitrile extracts into breast milk? Does Tc 99m hexakis-methoxyisobutylisonitrile has any long term or short term side effects on infants? Can Tc 99m hexakis-methoxyisobutylisonitrile influence milk supply or can Tc 99m hexakis-methoxyisobutylisonitrile decrease milk supply in lactating mothers?

Tc 99m hexakis-methoxyisobutylisonitrile lactation summary

Tc 99m hexakis-methoxyisobutylisonitrile usage has low risk in breastfeeding
  • DrLact safety Score for Tc 99m hexakis-methoxyisobutylisonitrile is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Tc 99m hexakis-methoxyisobutylisonitrile may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Tc 99m hexakis-methoxyisobutylisonitrile may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Tc 99m hexakis-methoxyisobutylisonitrile low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Tc 99m hexakis-methoxyisobutylisonitrile We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Tc 99m hexakis-methoxyisobutylisonitrile usage in lactation

Metastable Technetium 99 (99mTc) is a radioactive isotope that emits gamma radiation. Its radioactive decay half-life is 6.0 hours. After radioactive labelling with sodium pertechnetate (99mTc) solution, the technetium (99mTc) sestamibi solution obtained is used in single photon emission computed tomography (SPECT) for the diagnosis of myocardial, mammary and parathyroid disease. 0.05% of the administered dose is excreted in breast milk (Leide 2016, Liepe 2016). Breastfeeding interruption or close contact avoidance times are calculated so that the infant is not exposed to more than 1 millisievert (1 mSv = 0.1 rem) of radiation (ICRP 2008, Howe 2008, Stabin 2000). An adult receives between 5 and 10 mSv annually from environmental radiation. The main regulatory agencies which manage radioactive substances and experts consider that breastfeeding can occur immediately after a diagnostic test with Tc 99m sestamibi (ARSAC 2016, ICRP 2008, Howe 2008, Stabin 2000, Rubow 1994 and 1991). Some agencies (ARSAC 2016, ICRP 2008) consider it more prudent to discontinue breastfeeding for about 4 hours, expressing breast milk and instead offering milk previously expressed and stored in a refrigerator prior to testing.Milk expressed after feeding can be frozen and used after 10 radioactive half lives: 10 x 6.0 = 60 hours = 3 days (Hale 2017, p.1919). Close contact with the infant need not be avoided (Mountford 1999).
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.