Question

I am a breastfeeding mother and i want to know if it is safe to use Isonicotinohydrazide (INH)? Is Isonicotinohydrazide (INH) safe for nursing mother and child? Does Isonicotinohydrazide (INH) extracts into breast milk? Does Isonicotinohydrazide (INH) has any long term or short term side effects on infants? Can Isonicotinohydrazide (INH) influence milk supply or can Isonicotinohydrazide (INH) decrease milk supply in lactating mothers?

Isonicotinohydrazide (INH) lactation summary

Isonicotinohydrazide (INH) is safe in breastfeeding
  • DrLact safety Score for Isonicotinohydrazide (INH) is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Isonicotinohydrazide (INH) is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Isonicotinohydrazide (INH) does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Isonicotinohydrazide (INH) safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Isonicotinohydrazide (INH) usage in lactation

It is excreted into breast milk in clinically non-significant amount, in any case, much lower than the doses commonly used in newborns and infants (Snider 1984, Singh 2008). No significant problems have been observed in infants whose mothers were treated. (Drobac 2005). An infant whose mother was treated with anti-TBC drugs during pregnancy and lactation for 7 months, presented moderately high levels of liver transaminases along with a normal clinical and developmental course (Peters 2008). The plasma levels measured in any of those infants were undetectable or very low. Several medical societies and consensus of expert panels consider safe the use of this medication while breastfeeding (Dautzenberg 1988, Tran 1998, Blumberg 2003, Schram 2005, WHO 2007, Singh 2008, Baquero-Artigao 2015, Malhamé 2016).American Academy of Pediatrics: medication usually compatible with breastfeeding.WHO List of Essential Medicines 2002: compatible with breastfeeding. The addition of Vitamin B6 (Pyridoxine) to treatment of mother-infant dyad should be evaluated, especially in cases of malnutrition, diabetes, other diseases or a new pregnancy (Blumberg 2003, Steichen 2006, Baquero-Artigao 2015, 2016 Principi Di 2016).
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