Is Rabeprazole Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Rabeprazole? Is Rabeprazole safe for nursing mother and child? Does Rabeprazole extracts into breast milk? Does Rabeprazole has any long term or short term side effects on infants? Can Rabeprazole influence milk supply or can Rabeprazole decrease milk supply in lactating mothers?

At latest update, relevant information on excretion into breast milk was not found. Due to a high serum-protein-binding capacity, excretion of Rabeprazole into breast milk in significant levels is unlikely. Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Rabeprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food. Both Omeprazole and Pantoprazole pertain to the same chemical group with similar pharmacokinetics that are excreted in non-significant amount into the breast milk. No alteration on serum Prolactin level has been shown.

Because no information is available on the use of rabeprazole during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

The Spanish pharmacovigilance system found one case of a 90-year-old man who developed gynecomastia associated with rabeprazole reported during the time period of 1982 to 2006. The reaction occurred after 32 days of therapy and resolved after discontinuation of the drug.[1]