Is HSDB 7357 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 7357? Is HSDB 7357 safe for nursing mother and child? Does HSDB 7357 extracts into breast milk? Does HSDB 7357 has any long term or short term side effects on infants? Can HSDB 7357 influence milk supply or can HSDB 7357 decrease milk supply in lactating mothers?
HSDB 7357 lactation summary
- DrLact safety Score for HSDB 7357 is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of HSDB 7357 may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that HSDB 7357 may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using HSDB 7357 .
- Usage of HSDB 7357 is in contradiction to breastfeeding hence if it is must to use HSDB 7357 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 7357 usage in lactation
Withhold from market since 2001 because of severe and fatal side effects. Statin drugs do its action by inhibiting cholesterol synthesis. On latest update relevant data on breastfeeding was not found. Its high plasma protein binding makes excretion into breast milk unlikely. Ability to alter fat composition of breast milk is unknown which is important since infants are in need of high cholesterol intake for adequate brain development, cell membrane building and hormone and vitamin synthesis. Avoid taking it at least while exclusive breastfeeding. Atorvastatin is possibly the safest statin drug because a higher molecular weight that lowers excretion into breast milk even more extensively. For Pravastatin a minimal excretion has been reported. Simvastatin has a lowest oral bioavailability. Avoiding drug treatment for cholesterol as long as breastfeeding is desired would probably not harm long term result of disease. Continuing with a low fat containing diet is recommended.
Alternate Drugs for Lipid Modifying Agents HMG CoA reductase inhibitors. ATC C10AA
Atorvastatin(Unsafe)
Fluvastatin(Unsafe)
Lovastatin(Unsafe)
Pravastatin(Unsafe)
Rosuvastatin(Unsafe)
Simvastatin(Unsafe)
Atorvastatin Calcium(Unsafe)
Cerivastatin(Dangerous)
Rosuvastatin Calcium(Unsafe)
Pravastatin Sodium(Unsafe)
Mevinolin(Unsafe)
Monacolin K(Unsafe)
Fluvastatin Sodium(Unsafe)