Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-83MVU38M7Q? Is UNII-83MVU38M7Q safe for nursing mother and child? Does UNII-83MVU38M7Q extracts into breast milk? Does UNII-83MVU38M7Q has any long term or short term side effects on infants? Can UNII-83MVU38M7Q influence milk supply or can UNII-83MVU38M7Q decrease milk supply in lactating mothers?

UNII-83MVU38M7Q lactation summary

UNII-83MVU38M7Q is unsafe in breastfeeding
  • DrLact safety Score for UNII-83MVU38M7Q is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of UNII-83MVU38M7Q may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-83MVU38M7Q may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using UNII-83MVU38M7Q .
  • It is recommended to evaluate the advantage of not breastfeeding while using UNII-83MVU38M7Q Vs not using UNII-83MVU38M7Q And continue breastfeeding.
  • While using UNII-83MVU38M7Q Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-83MVU38M7Q usage in lactation

Statin pharmacologically acts by inhibiting cholesterol synthesis. Excretion into breast milk is non-significant. Its low oral biodisponibility makes absorption by the infant unlikely. Influence on alteration of breast milk fat composition is unknown. High amount of cholesterol is required by the infant to ensure appropriate development of nervous system, cell membranes and hormones or vitamin production. Avoiding use while exclusive breastfeeding would be advisable. Atorvastatin is probably safer because of a higher molecular weight that would interfer with excretion into breast milk. Pravastatin has also shown a low excretion. Simvastatin has the lowest oral biodisponibility. Interruption of drug hypercholesterolemia treatment while breastfeeding would probably not affect long-term outcome of the disease. A hypolipidemic diet should be followed.

Answer by DrLact: About UNII-83MVU38M7Q usage in lactation

Levels of rosuvastatin in milk are low, but no relevant published information exists with its use during breastfeeding. The consensus opinion is that women taking a statin should not breastfeed because of a concern with disruption of infant lipid metabolism. However, others have argued that children homozygous for familial hypercholesterolemia are treated with statins beginning at 1 year of age, that statins have low oral bioavailability, and risks to the breastfed infant are low, especially with rosuvastatin and pravastatin.[1] Until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Alternate Drugs for Lipid Modifying Agents HMG CoA reductase inhibitors. ATC C10AA

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.