Question

I am a breastfeeding mother and i want to know if it is safe to use Probucolum? Is Probucolum safe for nursing mother and child? Does Probucolum extracts into breast milk? Does Probucolum has any long term or short term side effects on infants? Can Probucolum influence milk supply or can Probucolum decrease milk supply in lactating mothers?

Probucolum lactation summary

Probucolum is unsafe in breastfeeding
  • DrLact safety Score for Probucolum is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of Probucolum may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that Probucolum may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using Probucolum .
  • It is recommended to evaluate the advantage of not breastfeeding while using Probucolum Vs not using Probucolum And continue breastfeeding.
  • While using Probucolum Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Probucolum usage in lactation

Reduces blood cholesterol levels by mechanisms that have not been not clarified.It accumulates for long periods in fatty tissues and has very slow elimination by bile. Since the last update we have not found published data in relation to breastfeeding. Cholesterol levels in milk are very stable even in hypercholesterolemic women and are not severely affected by diet or nutritional status of the mother, suggesting that 3 is synthesized, at least in part, in the mammary gland (Lawrence 2016, p 289-90).It is not probable therefore, but it is not known if Probucolum is able to alter the lipid composition of the milk. Infants need to ingest large amounts of cholesterol, as it is critical to the proper development of the nervous system, cell membranes and is a precursor of several hormones and vitamins. Until there is more data in relation to breastfeeding, it is prudent to avoid using it, at least while breastfeeding exclusively. Suspending the pharmacological treatment of hyperlipidemia during breastfeeding is not likely to alter the long-term outcome of the disease, especially when breastfeeding can be considered therapeutic (Lawrence 2016, p.393). It is advisable to follow a lipid-lowering diet. Because of its side effects in most countries the product has been withdrawn from sale or restrictions have been imposed on its approved use.

Alternate Drugs for Lipid Modifying Agents, other. ATC C10AX

Ezetimibe(Low Risk)
Probucol(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.