Is UNII-21HN3N72PV Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-21HN3N72PV? Is UNII-21HN3N72PV safe for nursing mother and child? Does UNII-21HN3N72PV extracts into breast milk? Does UNII-21HN3N72PV has any long term or short term side effects on infants? Can UNII-21HN3N72PV influence milk supply or can UNII-21HN3N72PV decrease milk supply in lactating mothers?
UNII-21HN3N72PV lactation summary
- DrLact safety Score for UNII-21HN3N72PV is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-21HN3N72PV is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-21HN3N72PV does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-21HN3N72PV safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-21HN3N72PV usage in lactation
Anticholinergic drug used as spasmolytic for functional gastrointestinal disorders. At latest update relevant published data on excretion into breast milk were not found. It acts locally on the intestinal mucosa. Absorption through the intestine is practically absent (Evangelista 2004, Catalogo 2008), with an excretion being almost 100% unmodified in feces that is determinant for the extremely low levels reached in the plasma (Zhao 2010: <0.02 mg / L), which causes the passage through breastmilk in significant amounts must be very unlikely.Side effects are mild and very rarely seen. Although anticholinergics may reduce milk production, however, because of its poor absorption it would not be the case with Otilonium.
Alternate Drugs for Drugs for functional bowel disorders (Anticholinergics, Antispasmodics). ATC A03A-B,
Dicyclomine(Unsafe)
Atropine(Safe)
Glycopyrrolate(Unsafe)
Belladona(Unsafe)
Dicycloverine(Unsafe)
Phloroglucinol(Low Risk)
Otilonium Bromide(Safe)
Glycopyrronium Bromide(Unsafe)
Hyoscyamine(Low Risk)
Mebeverine Hydrochloride(Low Risk)
Pinaverium Bromide(Low Risk)
Prifinium Bromide(Low Risk)
Propantheline-Bromide(Low Risk)
Trimebutine maleate(Low Risk)
Piperidolate Hydrochloride(Low Risk)
Phloroglucin(Low Risk)
Daturine(Low Risk)