Is 5-Nor-anhydrovinblastine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 5-Nor-anhydrovinblastine? Is 5-Nor-anhydrovinblastine safe for nursing mother and child? Does 5-Nor-anhydrovinblastine extracts into breast milk? Does 5-Nor-anhydrovinblastine has any long term or short term side effects on infants? Can 5-Nor-anhydrovinblastine influence milk supply or can 5-Nor-anhydrovinblastine decrease milk supply in lactating mothers?
5-Nor-anhydrovinblastine lactation summary
- DrLact safety Score for 5-Nor-anhydrovinblastine is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of 5-Nor-anhydrovinblastine may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that 5-Nor-anhydrovinblastine may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using 5-Nor-anhydrovinblastine .
- Usage of 5-Nor-anhydrovinblastine is in contradiction to breastfeeding hence if it is must to use 5-Nor-anhydrovinblastine and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 5-Nor-anhydrovinblastine usage in lactation
Semi-synthetic vinca alkaloid with an anti-neoplastic activity similar to Vinblastine (see specific info).Indicated for the treatment of certain forms of lung and breast cancer.Routes of administration: intravenous and oral. At latest update relevant published data were not found on excretion into breast milk. In spite of a pharmacokinetic data (large volume of distribution, molecular weight and high binding capacity to blood cells, especially to platelets) that would make it unlikely the passage to milk of significant amounts along with a low bioavailability that would hinder the passage to infant plasma, most experts advise against the use of anti-neoplastic drugs during lactation due to a potential harmful effect on the infant (Pentheroudakis 2010, Koren 2013, pistil 2013, Anderson 2016) until safety data with relation to breastfeeding are provided.It has also been shown that anti-neoplastic drugs may alter the microbial flora balance of breastmilk (Urbaniak 2014). Whenever the option of continuing breastfeeding is preferred, it should be wait for a 5 half-lives period to resume breastfeeding, a period in which 97% of the drug would be eliminated from the body (Anderson 2016).In case of using such a drug it would be wise waiting for 10 days after the last dose to resume breastfeeding. Meanwhile, pump-and-dump regularly to keep production of breastmilk going.