I am a breastfeeding mother and i want to know if it is safe to use Trimethoprim? Is Trimethoprim safe for nursing mother and child? Does Trimethoprim extracts into breast milk? Does Trimethoprim has any long term or short term side effects on infants? Can Trimethoprim influence milk supply or can Trimethoprim decrease milk supply in lactating mothers?

Trimethoprim lactation summary

Trimethoprim is safe in breastfeeding
  • DrLact safety Score for Trimethoprim is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Trimethoprim is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Trimethoprim does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Trimethoprim safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Trimethoprim usage in lactation

It is excreted in breast milk in clinically non-significant amount. No problems have been observed in infants whose mothers were treated. Medication which is used in infants from the second month of age. Take into account the possibility of negative false results of cultures from febrile infants whose mothers are taking antibiotics as well as the possibility of acute diarrhea due to imbalance of the intestinal flora. The American Academy of Pediatric states that it is usually compatible with breastfeeding medication.WHO List of Essential Medicines from 2002 has classified it as compatible with breastfeeding.

Answer by DrLact: About Trimethoprim usage in lactation

Because of the low levels of trimethoprim in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Trimethoprim Side Effects in Breastfeeding

In one study, no adverse effects were noted in infants during 4 days of maternal therapy with co-trimoxazole.[1] In a telephone follow-up study, 12 nursing mothers reported taking co-trimoxazole (dosage unspecified). Two mothers reported poor feeding in their infants. Diarrhea was not reported among the exposed infants.[4]

Alternate Drugs

Nalidixic Acid(Low Risk)
Nalidixic Acid(Low Risk)
Capreomycin(Low Risk)
Gatifloxacin(Low Risk)
Enoxacin(Low Risk)
Doxycycline(Low Risk)
Moxifloxacin(Low Risk)
Demeclocycline(Low Risk)
Methicillin(Low Risk)
Erythromycin(Low Risk)
Lomefloxacin(Low Risk)
Clindamycin(Low Risk)
Levofloxacin(Low Risk)
Methotrexate(Low Risk)

Synonyms of Trimethoprim

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.