Is NSC-64393 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use NSC-64393? Is NSC-64393 safe for nursing mother and child? Does NSC-64393 extracts into breast milk? Does NSC-64393 has any long term or short term side effects on infants? Can NSC-64393 influence milk supply or can NSC-64393 decrease milk supply in lactating mothers?
NSC-64393 lactation summary
- DrLact safety Score for NSC-64393 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of NSC-64393 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that NSC-64393 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of NSC-64393 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About NSC-64393 usage in lactation
It is assumed that excretion into breast milk achieves bacteriostatic concentrations.A latest update no published data were found on excretion into breast milk. Because a high molecular weight it seems unlikely an excretion into breast milk in significant amount.A low oral bioavailability further reduced with simultaneous food intake impairs the appearance in the infant plasma from ingested milk except in preterm babies and those in the immediate neonatal period, which may have increased intestinal permeability. Macrolide-based medication that is used in infants.Until more published data on this drug regarding breastfeeding is available, safer alternatives with better known drugs should be preferable especially during the neonatal period and in case of prematurity.. Take into account the possible negative cultures in febrile infants whose mothers take antibiotics
Alternate Drugs for Macrolide, Lincosamide and Streptogramin antibacterials. ATC J01F
Azithromycin(Safe)
Clarithromycin(Safe)
Clindamycin(Low Risk)
Telithromycin(Unsafe)
Roxithromycin(Safe)
Dalfopristin(Low Risk)
Dirithromycin(Low Risk)
Spiramycin(Safe)
Josamycin(Low Risk)
Lincomycin(Safe)
Midecamycin(Low Risk)
Quinupristin(Low Risk)
Lincomycin Hydrochloride(Safe)