Question

I am a breastfeeding mother and i want to know if it is safe to use Sulfamethoxazole? Is Sulfamethoxazole safe for nursing mother and child? Does Sulfamethoxazole extracts into breast milk? Does Sulfamethoxazole has any long term or short term side effects on infants? Can Sulfamethoxazole influence milk supply or can Sulfamethoxazole decrease milk supply in lactating mothers?

Sulfamethoxazole lactation summary

Sulfamethoxazole is safe in breastfeeding
  • DrLact safety Score for Sulfamethoxazole is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Sulfamethoxazole is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Sulfamethoxazole does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Sulfamethoxazole safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Sulfamethoxazole usage in lactation

Excreted in non-significant levels into breast milk. No adverse effects have been shown in breastfed infants. Caution with those neonates suffering of hyperbilirrubinemia or G-6-P-D deficiency is required. Avoid use in affected patients Check-up for infant jaundice. Be aware of false negative results of bacterial cultures when the mother is on antibiotics. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Sulfamethoxazole usage in lactation

With healthy, fullterm infants it appears acceptable to use sulfamethoxazole during breastfeeding after the newborn period. The time of greatest risk for hemolysis in fullterm newborns without glucose-6-phosphate dehydrogenase (G6PD) deficiency might be as short as 8 days after birth.[1] Until further data are accumulated, alternate agents should probably be used in jaundiced, ill, stressed or premature infants, because of the risk of bilirubin displacement and kernicterus. Sulfamethoxazole should be avoided while breastfeeding a G6PD deficient infant.[2]

Sulfamethoxazole Side Effects in Breastfeeding

An extensive systematic review of the use of sulfonamides near term and during breastfeeding found no adverse reactions in infants. The authors concluded that use of sulfamethoxazole during breastfeeding presents no risk of neonatal kernicterus.[4] A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. Of 12 women who took sulfamethoxazole and trimethoprim during breastfeeding (time postpartum and dosage not reported), none reported diarrhea, drowsiness or irritability in her infant. Two mothers reported poor feeding in their infants.[5]

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.