Question

I am a breastfeeding mother and i want to know if it is safe to use Amantadine? Is Amantadine safe for nursing mother and child? Does Amantadine extracts into breast milk? Does Amantadine has any long term or short term side effects on infants? Can Amantadine influence milk supply or can Amantadine decrease milk supply in lactating mothers?

Amantadine lactation summary

Amantadine usage has low risk in breastfeeding
  • DrLact safety Score for Amantadine is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Amantadine may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Amantadine may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Amantadine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Amantadine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Amantadine usage in lactation

Antiviral used for treatment and prophylaxis of type-A Influenza. Since it is a dopamine agonist is also used to treat Parkinson’s disease. At latest update relevant published data on excretion into breast milk were not found. Because of large volume of distribution and low plasma level observed (Pacifici 1976), a passage of significant amount through breastmilk or side-effects on the infant are not likely to occur. Amantadine reduces plasma levels of prolactin, it has been used to treat galactorrhea caused by the use of dopaminergic neuroleptic drugs (Siever 1981 Correa 1987, Marken 1992, Carvalho 2011), however there is not information about the effect on lactating mothers. Prolactin is important to milk production especially during the first few weeks within birth. Frequent and effective stimulation of the nipple by the infant is essential on the maintenance of breastfeeding. Whether administered during breastfeeding, it would be advisable not to use it in the neonatal period and monitor milk production.

Answer by DrLact: About Amantadine usage in lactation

It is probably best to avoid amantadine during breastfeeding because of its potential negative effect on lactation.

Amantadine Possible Effects in Breastfeeding

Amantadine is a dopamine agonist. Clinical studies using amantadine dosages of 100 mg 2 or 3 times daily have demonstrated a decrease in serum prolactin and decreased galactorrhea in patients taking dopaminergic neuroleptic drugs such as phenothiazines, haloperidol and loxapine.[1][2] No studies have been reported on the effects of amantadine on the milk supply in nursing mothers. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.