Question

I am a breastfeeding mother and i want to know if it is safe to use CCRIS 5490? Is CCRIS 5490 safe for nursing mother and child? Does CCRIS 5490 extracts into breast milk? Does CCRIS 5490 has any long term or short term side effects on infants? Can CCRIS 5490 influence milk supply or can CCRIS 5490 decrease milk supply in lactating mothers?

CCRIS 5490 lactation summary

CCRIS 5490 is safe in breastfeeding
  • DrLact safety Score for CCRIS 5490 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of CCRIS 5490 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that CCRIS 5490 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of CCRIS 5490 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About CCRIS 5490 usage in lactation

An antibacterial with very few bibliographical references which is used with little evidence of its efficacy (N.A.L. Prescrire 2004 and 1999) in the treatment of acute gastroenteritis of bacterial origin. Since the last update we have not found published data about its excretion in breast milk. It has a very low oral bioavailability, due to low or zero intestinal absorption (Armstrong 2015), making it unlikely its would pass into breast milk. Its low oral bioavailability would also further complicate its passing into the infant’s plasma via ingested breast milk, except in premature babies and in the immediate neonatal period during which there may be greater intestinal permeability.

Alternate Drugs for Antidiarrheals: Intestinal anti-infectives, adsorbents, electrolytes, anti-propulsive, anti-inflammatory and microorganisms agents. ATC A07

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