Is Polymyxin E Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Polymyxin E? Is Polymyxin E safe for nursing mother and child? Does Polymyxin E extracts into breast milk? Does Polymyxin E has any long term or short term side effects on infants? Can Polymyxin E influence milk supply or can Polymyxin E decrease milk supply in lactating mothers?
Polymyxin E lactation summary
- DrLact safety Score for Polymyxin E is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Polymyxin E is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Polymyxin E does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Polymyxin E safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Polymyxin E usage in lactation
Pharmacokinetic data (high volume of distribution and molecular weight) would explain the minimal excretion into breast milk mentioned in two older reports. Due to a poor oral bioavailability, appearance in the infant's plasma from ingested milk is regarded as nil or scanty, except in premature infants or during the immediate neonatal period who may show an increased intestinal absorption.
Answer by DrLact: About Polymyxin E usage in lactation
Limited data indicate that Polymyxin E is minimally excreted into breastmilk following intramuscular administration of colistimethate. Because Polymyxin E is poorly absorbed orally, it is unlikely to be absorbed in appreciable amounts by the infant or adversely affect the breastfed infant. However, no studies have evaluated serum levels or adverse effects in breastfed infants whose mothers were receiving colistimethate. Breastfeeding is acceptable with the use of inhaled Polymyxin E or colistimethate.
Alternate Drugs for Antidiarrheals: Intestinal anti-infectives, adsorbents, electrolytes, anti-propulsive, anti-inflammatory and microorganisms agents. ATC A07
Loperamide(Safe)
Mesalamine(Safe)
Olsalazine(Safe)
Sulfasalazine(Safe)
Colistimethate(Safe)
Cromolyn(Safe)
Polymyxin B(Safe)
Rifaximin(Safe)
Saccharomyces boulardii(Safe)
Pectin(Safe)
Nifuroxazide(Safe)
Bismuth salts(Safe)
Kaolin(Safe)
Activated Charcoal(Safe)
Colistin(Safe)
Sodium Cromoglicate(Safe)
Diphenoxilate-Hcl(Low Risk)
Mesalazine(Safe)
Polymyxin B Sulfate(Safe)
Racecadotril(Safe)
Rifaxidin(Safe)
Olsalazine Sodium(Safe)
Salazosulfapyridine(Safe)
Cromolyn Sodium(Safe)
5-Aminosalicylic Acid(Safe)
5-ASA(Safe)
Acetorphan(Safe)