Is (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester? Is (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester safe for nursing mother and child? Does (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester extracts into breast milk? Does (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester has any long term or short term side effects on infants? Can (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester influence milk supply or can (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester decrease milk supply in lactating mothers?
(+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester lactation summary
- DrLact safety Score for (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About (+-)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester usage in lactation
An anti-enkephalin that decreases intestinal secretion. Since the latest update, we have not found published data on its excretion in breast milk. Its high percentage of protein binding makes it unlikely it will transfer to milk in significant quantities. Possible side effects are not serious or frequent. Its use is authorized in infants from 3 months of age (Pediamecum 2015) Its indiscriminate use in treating gastroenteritis is not justified. Most cases of gastroenteritis do not require medication: good hydration is sufficient, even more so in the case of a breastfeeding mother.
Alternate Drugs for Antidiarrheals: Intestinal anti-infectives, adsorbents, electrolytes, anti-propulsive, anti-inflammatory and microorganisms agents. ATC A07
Loperamide(Safe)
Mesalamine(Safe)
Olsalazine(Safe)
Sulfasalazine(Safe)
Colistimethate(Safe)
Cromolyn(Safe)
Polymyxin B(Safe)
Rifaximin(Safe)
Saccharomyces boulardii(Safe)
Pectin(Safe)
Nifuroxazide(Safe)
Bismuth salts(Safe)
Kaolin(Safe)
Activated Charcoal(Safe)
Colistin(Safe)
Sodium Cromoglicate(Safe)
Diphenoxilate-Hcl(Low Risk)
Mesalazine(Safe)
Polymyxin B Sulfate(Safe)
Racecadotril(Safe)
Rifaxidin(Safe)
Olsalazine Sodium(Safe)
Salazosulfapyridine(Safe)
Cromolyn Sodium(Safe)
5-Aminosalicylic Acid(Safe)
5-ASA(Safe)
Acetorphan(Safe)