Is UNII-H8A007M585 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-H8A007M585? Is UNII-H8A007M585 safe for nursing mother and child? Does UNII-H8A007M585 extracts into breast milk? Does UNII-H8A007M585 has any long term or short term side effects on infants? Can UNII-H8A007M585 influence milk supply or can UNII-H8A007M585 decrease milk supply in lactating mothers?
UNII-H8A007M585 lactation summary
- DrLact safety Score for UNII-H8A007M585 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of UNII-H8A007M585 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that UNII-H8A007M585 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of UNII-H8A007M585 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using UNII-H8A007M585 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-H8A007M585 usage in lactation
Opioid analgesic which is used for treatment of chronic pain. At latest update, relevant data on its excretion into breast milk were not found. Despite of a low molecular weight and a low serum-protein binding capacity that would favor excretion into the milk, its high value of volume distribution would permit a shorter permanence in the blood that would hamper its excretion. A low oral bioavailability would hamper absorption from ingested mother's milk, except among newborn infants o prematures, who may attain an increased absorption capacity. The risk for the infants would be minimized if the breast feed is avoided within 1 to 4 hours (non-depot formulation), or, within 3 to 6 hours (depot formulation) after taking medication. Until more information on this drug is available, other options that are known to be safer are recommended, especially when the baby is a newborn or a premature. Follow-up of symptoms as sedation or gastrointestinal disorders is recommended.
Alternate Drugs for Analgesics Opioids. ATC N02A
Buprenorphine(Safe)
Butorphanol(Low Risk)
Codeine(Unsafe)
Fentanyl(Safe)
Hydrocodone(Low Risk)
Meperidine(Low Risk)
Methadone(Safe)
Morphine(Low Risk)
Oxycodone(Unsafe)
Pentazocine(Low Risk)
Propoxyphene(Safe)
Tramadol(Safe)
Dihydrocodeine(Low Risk)
Dextropropoxyphene(Safe)
Methadone Hydrochloride(Safe)
Hydromorphone-Hcl(Low Risk)
Nalbuphine-Hcl(Low Risk)
Paregoric(Low Risk)
Pethidine Hydrochloride(Low Risk)
Tapentadol(Low Risk)
Meperidine Hydrochloride(Low Risk)
Codeine Phosphate(Unsafe)
Codeine Sulfate(Unsafe)
Methylmorphine(Unsafe)