Is D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH? Is D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH safe for nursing mother and child? Does D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH extracts into breast milk? Does D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH has any long term or short term side effects on infants? Can D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH influence milk supply or can D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH decrease milk supply in lactating mothers?
D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH lactation summary
- DrLact safety Score for D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH usage in lactation
It is a GNRH analogue that works like an inhibitor of Hypophysis Gonadotropin (LH & FSH) secretion. A continue use produces a decrease of Estradiol level to those seen during the post-menopause period. A decrease of breast milk production is possible. When used for the treatment of infertility, the anovulatory effect of breastfeeding should be taken into account, if it is done with a frequent on-demand feeding. At latest update, no relevant published data concerning excretion into breast milk were found. Its high molecular weight makes excretion into breast milk be unlikely. Also, a low oral bioavailability renders the absorption of this agent into the infant's plasma be nil or minimal.
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