Question

I am a breastfeeding mother and i want to know if it is safe to use Diferelin? Is Diferelin safe for nursing mother and child? Does Diferelin extracts into breast milk? Does Diferelin has any long term or short term side effects on infants? Can Diferelin influence milk supply or can Diferelin decrease milk supply in lactating mothers?

Diferelin lactation summary

Diferelin usage has low risk in breastfeeding
  • DrLact safety Score for Diferelin is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Diferelin may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Diferelin may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Diferelin low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Diferelin We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Diferelin usage in lactation

Gonadotropin releasing hormone analogue. It is not secreted into breast milk because of a large molecular weight. It is readily destroyed by the child’s stomach acid milieu. Follow-up breast milk production. Keep in mind that there is a known anovulatory effect of lactation that is related to sucking frequency.

Alternate Drugs for Antineoplastics: Hormonal, analogues and antagonists agents. ATC L02

Tamoxifen(Dangerous)
Letrozole(Dangerous)
Buserelin(Low Risk)
Goserelin(Low Risk)
Leuprorelin(Low Risk)
Triptorelin(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.