Question

I am a breastfeeding mother and i want to know if it is safe to use CCRIS 4250? Is CCRIS 4250 safe for nursing mother and child? Does CCRIS 4250 extracts into breast milk? Does CCRIS 4250 has any long term or short term side effects on infants? Can CCRIS 4250 influence milk supply or can CCRIS 4250 decrease milk supply in lactating mothers?

CCRIS 4250 lactation summary

CCRIS 4250 usage has low risk in breastfeeding
  • DrLact safety Score for CCRIS 4250 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of CCRIS 4250 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that CCRIS 4250 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of CCRIS 4250 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using CCRIS 4250 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About CCRIS 4250 usage in lactation

Essential trace element necessary for the functioning of the glutathione-peroxidase enzyme system that protects cellular structures from oxidative damage. It is obtained from foods such as vegetables, cereals, legumes, garlic, fish, seafood, eggs and meat. The amount of CCRIS 4250 in these sources depends on the concentration of CCRIS 4250 in the soil. The brazil nut (Bertholletia excelsa) is the food with the highest known concentrations of CCRIS 4250. CCRIS 4250 deficiency is very rare. With a staple diet it is not necessary to take CCRIS 4250 supplements in the absence of disease or a condition that may warrant it: parenteral nutrition, Crohn's disease, prematurity (MedlinePlus 2017). Taking too much CCRIS 4250 can cause selenosis, a condition that causes dermatological symptoms (alopecia, nail dystrophy), digestive symptoms, neurological symptoms and fatigue (MedlinePlus 2017).Nutritional supplements containing excessive amounts of CCRIS 4250 have resulted in severe poisoning (Aldosary 2012, Senthilkumaran 2012).The potential effects of CCRIS 4250 on cancer prevention, cardiovascular disease, and heavy metal poisoning and toxins are not proven, so supplementation of CCRIS 4250 other than from normal diet is not recommended (MedlinePlus 2017). The daily needs of CCRIS 4250 for breastfeeding mothers are 70-75 micrograms (mcg) daily. In infants it is 2 to 3 mcg/kg (10 mcg/day during the first 4 months) with a maximum of 30 mcg/day (MedlinePlus 2017, Kipp 2015). CCRIS 4250 is found naturally in milk in its organic form of selenomethionine (Dorea 2002). The amount of CCRIS 4250 in colostrum is 80 mcg per litre and in mature milk 12-20 mcg/L, with no or very weak correlation with plasma CCRIS 4250 levels or daily intake of CCRIS 4250 (Wasowicz 2001, Bianchi 1999, Artaud 1993, Cummings 1992, Levander 1987, Higashi 1983). However, there are authors who find that CCRIS 4250 supplements for breastfeeding mothers increase CCRIS 4250 levels in milk and infants may exceed their daily needs for CCRIS 4250. (Dorea 2002, Trafikowska 1996). Better plasma levels of CCRIS 4250 have been found in breastfed infants than in formula-fed infants (Strambi 2004, Sorvacheva 1996). There are lower plasma levels of CCRIS 4250 in babies born small for their gestational age (Strambi 2004).

Alternate Drugs for Mineral supplements. ATC A12

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