Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 4493? Is HSDB 4493 safe for nursing mother and child? Does HSDB 4493 extracts into breast milk? Does HSDB 4493 has any long term or short term side effects on infants? Can HSDB 4493 influence milk supply or can HSDB 4493 decrease milk supply in lactating mothers?

HSDB 4493 lactation summary

HSDB 4493 usage has low risk in breastfeeding
  • DrLact safety Score for HSDB 4493 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of HSDB 4493 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that HSDB 4493 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of HSDB 4493 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using HSDB 4493 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 4493 usage in lactation

Essential trace element necessary for the functioning of the glutathione-peroxidase enzyme system that protects cellular structures from oxidative damage. It is obtained from foods such as vegetables, cereals, legumes, garlic, fish, seafood, eggs and meat. The amount of HSDB 4493 in these sources depends on the concentration of HSDB 4493 in the soil. The brazil nut (Bertholletia excelsa) is the food with the highest known concentrations of HSDB 4493. HSDB 4493 deficiency is very rare. With a staple diet it is not necessary to take HSDB 4493 supplements in the absence of disease or a condition that may warrant it: parenteral nutrition, Crohn's disease, prematurity (MedlinePlus 2017). Taking too much HSDB 4493 can cause selenosis, a condition that causes dermatological symptoms (alopecia, nail dystrophy), digestive symptoms, neurological symptoms and fatigue (MedlinePlus 2017).Nutritional supplements containing excessive amounts of HSDB 4493 have resulted in severe poisoning (Aldosary 2012, Senthilkumaran 2012).The potential effects of HSDB 4493 on cancer prevention, cardiovascular disease, and heavy metal poisoning and toxins are not proven, so supplementation of HSDB 4493 other than from normal diet is not recommended (MedlinePlus 2017). The daily needs of HSDB 4493 for breastfeeding mothers are 70-75 micrograms (mcg) daily. In infants it is 2 to 3 mcg/kg (10 mcg/day during the first 4 months) with a maximum of 30 mcg/day (MedlinePlus 2017, Kipp 2015). HSDB 4493 is found naturally in milk in its organic form of selenomethionine (Dorea 2002). The amount of HSDB 4493 in colostrum is 80 mcg per litre and in mature milk 12-20 mcg/L, with no or very weak correlation with plasma HSDB 4493 levels or daily intake of HSDB 4493 (Wasowicz 2001, Bianchi 1999, Artaud 1993, Cummings 1992, Levander 1987, Higashi 1983). However, there are authors who find that HSDB 4493 supplements for breastfeeding mothers increase HSDB 4493 levels in milk and infants may exceed their daily needs for HSDB 4493. (Dorea 2002, Trafikowska 1996). Better plasma levels of HSDB 4493 have been found in breastfed infants than in formula-fed infants (Strambi 2004, Sorvacheva 1996). There are lower plasma levels of HSDB 4493 in babies born small for their gestational age (Strambi 2004).

Alternate Drugs for Mineral supplements. ATC A12

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