Is 1-34-Human PTH Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 1-34-Human PTH? Is 1-34-Human PTH safe for nursing mother and child? Does 1-34-Human PTH extracts into breast milk? Does 1-34-Human PTH has any long term or short term side effects on infants? Can 1-34-Human PTH influence milk supply or can 1-34-Human PTH decrease milk supply in lactating mothers?
1-34-Human PTH lactation summary
- DrLact safety Score for 1-34-Human PTH is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of 1-34-Human PTH may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that 1-34-Human PTH may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of 1-34-Human PTH low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using 1-34-Human PTH We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 1-34-Human PTH usage in lactation
Synthetic polypeptide with (1-34) amino acid at N-terminal region of the parathyroid hormone (PTH) with similar biological activity to PTH. PTH peptides found in breast milk and seem to be related to the excretion of calcium in milk. At last update no published data on excretion in breast milk were found . A high molecular weight and rapid metabolism (Tmax and T1 / 2) make it unlikely excretion into milk in significant amount. The low oral-bioavailability makes drug levels in the infant's plasma from ingested breast milk be nil or negligible, except in premature babies and/or immediate neonatal period when they may exhibit an increased intestinal absorption.