Question

I am a breastfeeding mother and i want to know if it is safe to use Cefamandol [INN-Spanish]? Is Cefamandol [INN-Spanish] safe for nursing mother and child? Does Cefamandol [INN-Spanish] extracts into breast milk? Does Cefamandol [INN-Spanish] has any long term or short term side effects on infants? Can Cefamandol [INN-Spanish] influence milk supply or can Cefamandol [INN-Spanish] decrease milk supply in lactating mothers?

Cefamandol [INN-Spanish] lactation summary

Cefamandol [INN-Spanish] is safe in breastfeeding
  • DrLact safety Score for Cefamandol [INN-Spanish] is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Cefamandol [INN-Spanish] is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Cefamandol [INN-Spanish] does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Cefamandol [INN-Spanish] safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Cefamandol [INN-Spanish] usage in lactation

Second-generation cephalosporins for injection or parenteral administration. At latest update no published data on excretion into breast milk were found. Pharmacokinetic data (short half-life span) make unlikely the milk passage of significant amounts into breast milk.Their low oral bioavailability hinders the passage from ingested milk to the infant’s plasma except in preterm babies and immediate neonatal period, when they may exhibit an increased intestinal permeability. Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants. Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.