Question

I am a breastfeeding mother and i want to know if it is safe to use Compound 83405? Is Compound 83405 safe for nursing mother and child? Does Compound 83405 extracts into breast milk? Does Compound 83405 has any long term or short term side effects on infants? Can Compound 83405 influence milk supply or can Compound 83405 decrease milk supply in lactating mothers?

Compound 83405 lactation summary

Compound 83405 is safe in breastfeeding
  • DrLact safety Score for Compound 83405 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Compound 83405 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Compound 83405 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Compound 83405 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Compound 83405 usage in lactation

Second-generation cephalosporins for injection or parenteral administration. At latest update no published data on excretion into breast milk were found. Pharmacokinetic data (short half-life span) make unlikely the milk passage of significant amounts into breast milk.Their low oral bioavailability hinders the passage from ingested milk to the infant’s plasma except in preterm babies and immediate neonatal period, when they may exhibit an increased intestinal permeability. Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants. Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.