Question

I am a breastfeeding mother and i want to know if it is safe to use RB 1489? Is RB 1489 safe for nursing mother and child? Does RB 1489 extracts into breast milk? Does RB 1489 has any long term or short term side effects on infants? Can RB 1489 influence milk supply or can RB 1489 decrease milk supply in lactating mothers?

RB 1489 lactation summary

RB 1489 is unsafe in breastfeeding
  • DrLact safety Score for RB 1489 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of RB 1489 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that RB 1489 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using RB 1489 .
  • It is recommended to evaluate the advantage of not breastfeeding while using RB 1489 Vs not using RB 1489 And continue breastfeeding.
  • While using RB 1489 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About RB 1489 usage in lactation

Quinolone derivative drugs may pose a problem on those patients affected of glycose-6-phosphate dehydrogenasa deficiency. Recently, quinolone-related medication has been used in neonates and infants without apparent side effects. It trespasses in tiny amounts into breast milk. Absorption through the child’s gut may be interfered by the calcium contained in the milk. Should it be necessary to prescribe it to a nursing mother, Norfloxacine, Ofloxacine and Ciprofloxacine have shown a lower level in the milk and thus must be the preferred drugs. Because a case of pseudomembranose colitis has been described possibly related to mother ingestion of Ciporfloxacine in a premature infant previously affected of NEC, a close follow-up for diarrhea is warranted. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Alternate Drugs for Quinolone antibacterials. ATC J01M

Enoxacin(Low Risk)
Gatifloxacin(Low Risk)
Levofloxacin(Low Risk)
Lomefloxacin(Low Risk)
Moxifloxacin(Low Risk)
Nalidixic Acid(Low Risk)
Ofloxacin(Safe)
Garenoxacin(Low Risk)
Pefloxacin(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.