Question

I am a breastfeeding mother and i want to know if it is safe to use BIBR 1048? Is BIBR 1048 safe for nursing mother and child? Does BIBR 1048 extracts into breast milk? Does BIBR 1048 has any long term or short term side effects on infants? Can BIBR 1048 influence milk supply or can BIBR 1048 decrease milk supply in lactating mothers?

BIBR 1048 lactation summary

BIBR 1048 is unsafe in breastfeeding
  • DrLact safety Score for BIBR 1048 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of BIBR 1048 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that BIBR 1048 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using BIBR 1048 .
  • It is recommended to evaluate the advantage of not breastfeeding while using BIBR 1048 Vs not using BIBR 1048 And continue breastfeeding.
  • While using BIBR 1048 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About BIBR 1048 usage in lactation

It is a thrombin inhibitor usually given by mouth. Used for the prevention of thrombotic embolism after hip or knee reconstructive surgery. It is not better than Enoxaparin but more expensive. Because of molecular characteristics it seems likely to trespass to breast-milk.

Alternate Drugs for Antithrombotic agents: direct thrombin inhibitors. ATC B01AE

Lepirudin(Low Risk)
Desirudin(Unsafe)
Argatroban(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.