Question

I am a breastfeeding mother and i want to know if it is safe to use Colistimethate? Is Colistimethate safe for nursing mother and child? Does Colistimethate extracts into breast milk? Does Colistimethate has any long term or short term side effects on infants? Can Colistimethate influence milk supply or can Colistimethate decrease milk supply in lactating mothers?

Colistimethate lactation summary

Colistimethate is safe in breastfeeding
  • DrLact safety Score for Colistimethate is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Colistimethate is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Colistimethate does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Colistimethate safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Colistimethate usage in lactation

Pharmacokinetic data (high volume of distribution and molecular weight) would explain the minimal excretion into breast milk mentioned in two older reports. Due to a poor oral bioavailability, appearance in the infant's plasma from ingested milk is regarded as nil or scanty, except in premature infants or during the immediate neonatal period who may show an increased intestinal absorption.

Answer by DrLact: About Colistimethate usage in lactation

Limited data indicate that colistin is minimally excreted into breastmilk following intramuscular administration of colistimethate. Because colistin is poorly absorbed orally, it is unlikely to be absorbed in appreciable amounts by the infant or adversely affect the breastfed infant. However, no studies have evaluated serum levels or adverse effects in breastfed infants whose mothers were receiving colistimethate. Breastfeeding is acceptable with the use of inhaled colistin or colistimethate.

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.