Is AL-281 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use AL-281? Is AL-281 safe for nursing mother and child? Does AL-281 extracts into breast milk? Does AL-281 has any long term or short term side effects on infants? Can AL-281 influence milk supply or can AL-281 decrease milk supply in lactating mothers?
AL-281 lactation summary
- DrLact safety Score for AL-281 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of AL-281 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that AL-281 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of AL-281 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About AL-281 usage in lactation
Local anesthetic agent which is used for infiltration and nerve-blocking procedures included Epidural anesthesia. It is excreted into breast milk in non-significant amount, with no side-effect observed on breastfed infants of treated mothers. Plasma levels in those infant were undetectable. There is controversy about the effect of drug-mediated analgesia used during the child birth (e.g. epidural injection of local anesthetics plus Fentanyl or alone) on the mature milk coming in, whether by delaying the onset of Lactogenesis phase II, or, by affecting the ability of the child for sucking. Some studies have shown a higher risk for delay of initiation of Lactogenesis phase II (milk coming in) longer than 3 post-natal days, but without effect on loss of initial weight. On other studies, the newborn infant appears to have higher risk for delay on first latch-on, higher body temperature and irritability or somnolence. Because of the latter, it is argued that those mothers would be in need of more support on breastfeeding when they have received ante or intra partum analgesia. However, some studies that have used Ropivacaine did not get such findings. There is consensus on the achievement of higher milk production and higher body weight increase in the neonate with an adequate pharmacological control of pain after C-section or vaginal childbirth.