Is U 14812 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use U 14812? Is U 14812 safe for nursing mother and child? Does U 14812 extracts into breast milk? Does U 14812 has any long term or short term side effects on infants? Can U 14812 influence milk supply or can U 14812 decrease milk supply in lactating mothers?

U 14812 lactation summary

U 14812 usage has low risk in breastfeeding

DrLact safety Score for U 14812 is 3 out of 8 which is considered Low Risk as per our analyses.
A safety Score of 3 indicates that usage of U 14812 may cause some minor side effects in breastfed baby.
Our study of different scientific research indicates that U 14812 may cause moderate to no side effects in lactating mother.
Most of scientific studies and research papers declaring usage of U 14812 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
While using U 14812 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About U 14812 usage in lactation

Sulfonilurea drugs stimulate secretion of endogen insulin. Oral anti-diabetic drugs are useless for treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower serum glucose level. See section on Maternal diabetes mellitus

Answer by DrLact: About U 14812 usage in lactation

Because no information is available on the use of U 14812 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Alternate Drugs

Exenatide

Liraglutide(Low Risk)

Acetohexamide(Low Risk)

Tolazamide

Lixisenatide

Acarbose(Safe)

Rosiglitazone(Low Risk)

Repaglinide(Unsafe)

Pramlintide

Pioglitazone(Low Risk)

Ertugliflozin

Nateglinide(Unsafe)

Empagliflozin(Unsafe)

Metformin(Safe)

Dapagliflozin(Unsafe)

Insulin(Safe)

Alogliptin(Low Risk)

Canagliflozin

Glyburide(Safe)

Linagliptin(Low Risk)

Sitagliptin(Low Risk)

Glipizide(Safe)

Saxagliptin(Low Risk)

Colesevelam(Safe)

Glimepiride(Unsafe)

Miglitol(Safe)

Semaglutide

Dulaglutide(Low Risk)

Chlorpropamide(Low Risk)

Tolbutamide(Safe)