Is NCI-C03247 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use NCI-C03247? Is NCI-C03247 safe for nursing mother and child? Does NCI-C03247 extracts into breast milk? Does NCI-C03247 has any long term or short term side effects on infants? Can NCI-C03247 influence milk supply or can NCI-C03247 decrease milk supply in lactating mothers?

NCI-C03247 lactation summary

NCI-C03247 usage has low risk in breastfeeding

DrLact safety Score for NCI-C03247 is 3 out of 8 which is considered Low Risk as per our analyses.
A safety Score of 3 indicates that usage of NCI-C03247 may cause some minor side effects in breastfed baby.
Our study of different scientific research indicates that NCI-C03247 may cause moderate to no side effects in lactating mother.
Most of scientific studies and research papers declaring usage of NCI-C03247 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
While using NCI-C03247 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NCI-C03247 usage in lactation

Sulfonilurea drugs stimulate secretion of endogen insulin. Oral anti-diabetic drugs are useless for treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower serum glucose level. See section on Maternal diabetes mellitus

Answer by DrLact: About NCI-C03247 usage in lactation

Because no information is available on the use of NCI-C03247 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Alternate Drugs

Saxagliptin(Low Risk)

Glipizide(Safe)

Colesevelam(Safe)

Glimepiride(Unsafe)

Miglitol(Safe)

Semaglutide

Dulaglutide(Low Risk)

Chlorpropamide(Low Risk)

Tolbutamide(Safe)

Exenatide

Liraglutide(Low Risk)

Acetohexamide(Low Risk)

Tolazamide

Lixisenatide

Acarbose(Safe)

Rosiglitazone(Low Risk)

Pramlintide

Repaglinide(Unsafe)

Ertugliflozin

Pioglitazone(Low Risk)

Empagliflozin(Unsafe)

Nateglinide(Unsafe)

Dapagliflozin(Unsafe)

Metformin(Safe)

Alogliptin(Low Risk)

Insulin(Safe)

Canagliflozin

Linagliptin(Low Risk)

Glyburide(Safe)

Sitagliptin(Low Risk)