I am a breastfeeding mother and i want to know if it is safe to use UNII-I65MW4OFHZ? Is UNII-I65MW4OFHZ safe for nursing mother and child? Does UNII-I65MW4OFHZ extracts into breast milk? Does UNII-I65MW4OFHZ has any long term or short term side effects on infants? Can UNII-I65MW4OFHZ influence milk supply or can UNII-I65MW4OFHZ decrease milk supply in lactating mothers?

UNII-I65MW4OFHZ lactation summary

UNII-I65MW4OFHZ is safe in breastfeeding
  • DrLact safety Score for UNII-I65MW4OFHZ is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of UNII-I65MW4OFHZ is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that UNII-I65MW4OFHZ does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of UNII-I65MW4OFHZ safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-I65MW4OFHZ usage in lactation

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation. Breastfed infants have not shown any problem after 1.5 to 5 hours of anesthesia time period with Rocuronio (additional drugs like Propofol, Remifentanil and Xenon were used). A high molecular weight may decrease excretion into breast milk as well as a rapid elimination time. In addition, a low oral bioavailability makes unlikely a pass from ingested mother's milk onto the infant's plasma. Rocuronium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition.

Answer by DrLact: About UNII-I65MW4OFHZ usage in lactation

Limited information on the use of rocuronium during breastfeeding indicates that no adverse infant effects occur. Because it is short acting, highly polar and poorly absorbed orally, it is not likely to reach the breastmilk in high concentration or to reach the bloodstream of the infant.[1][2] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. General anesthesia for cesarean section using rocuronium as a component may delay the onset of lactation.

UNII-I65MW4OFHZ Side Effects in Breastfeeding

Four mothers who underwent general anesthesia were given propofol and remifentanil as induction agents and rocuronium for intubation. After induction, propofol was stopped and xenon inhalation was used to maintain anesthesia for between 57 and 70 minutes. Infants resumed breastfeeding from 1.5 to 5 hours after the end of surgery. None of the infants had noticeable symptoms of dizziness or drowsiness. All infants fared well at home after their mothers were discharged.[3]

UNII-I65MW4OFHZ Possible Effects in Breastfeeding

A randomized study compared the effects of cesarean section using general anesthesia, spinal anesthesia, or epidural anesthesia, to normal vaginal delivery on serum prolactin and oxytocin as well as time to initiation of lactation. General anesthesia was performed using propofol 2 mg/kg and rocuronium 0.6 mg/kg for induction, followed by sevoflurane and rocuronium 0.15 mg/kg as needed. After delivery, patients in all groups received an infusion of oxytocin 30 international units in 1 L of saline, and 0.2 mg of methylergonovine if they were not hypertensive. Fentanyl 1 to 1.5 mcg/kg was administered after delivery to the general anesthesia group. Patients in the general anesthesia group (n = 21) had higher post-procedure prolactin levels and a longer mean time to lactation initiation (25 hours) than in the other groups (10.8 to 11.8 hours). Postpartum oxytocin levels in the nonmedicated vaginal delivery group were higher than in the general and spinal anesthesia groups.[4]
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