Is Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1)? Is Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) safe for nursing mother and child? Does Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) extracts into breast milk? Does Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) has any long term or short term side effects on infants? Can Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) influence milk supply or can Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) decrease milk supply in lactating mothers?
Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) lactation summary
- DrLact safety Score for Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, hydrochloride (1:1) usage in lactation
Second generation antihistamine drug derived from piperazine with a minimal sedative effect and low toxicity even at higher dose. On latest update no published data about breastfeeding were found. However, it is the R-enantiomer of cetirizine which is considered to be safe while breastfeeding. No short or long-term side effects were found in an infant with a mother who was treated with Cetirizine in the first month post delivery for pemphigus (Westermann 2012). Because of a high plasma protein binding capacity, excretion into breast milk seems to be unlikely. The British Society of Immunology and Allergy rates Cetirizine as compatible with breastfeeding (Powell 2007).