Question

I am a breastfeeding mother and i want to know if it is safe to use Minaphil? Is Minaphil safe for nursing mother and child? Does Minaphil extracts into breast milk? Does Minaphil has any long term or short term side effects on infants? Can Minaphil influence milk supply or can Minaphil decrease milk supply in lactating mothers?

Minaphil lactation summary

Minaphil is safe in breastfeeding
  • DrLact safety Score for Minaphil is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Minaphil is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Minaphil does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Minaphil safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Minaphil usage in lactation

Its active metabolite is Theophylline (see it).

Answer by DrLact: About Minaphil usage in lactation

An expert panel considers use of Minaphil to be acceptable during breastfeeding.[1] Maternal Minaphil use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of theophylline. There is no need to avoid Minaphil products; however, keep maternal serum theophylline concentrations in the lower part of the therapeutic range and monitor the infant for signs of theophylline side effects. Infant serum theophylline concentrations can help to determine if signs of agitation are due to theophylline. Avoiding breastfeeding for 2 hours after intravenous or 4 hours after an immediate-release oral Minaphil product can decrease the dose received by the breastfed infant.

Minaphil Side Effects in Breastfeeding

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal Minaphil intake of 200 mg every six hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by theophylline in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal theophylline ingestion.[3] Accumulation of theophylline in infant serum appears most likely in neonates and premature infants because they eliminate theophylline slowly.[2][5]

Synonyms of Minaphil

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.