Question

I am a breastfeeding mother and i want to know if it is safe to use 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1)? Is 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) safe for nursing mother and child? Does 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) extracts into breast milk? Does 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) has any long term or short term side effects on infants? Can 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) influence milk supply or can 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) decrease milk supply in lactating mothers?

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) lactation summary

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) is safe in breastfeeding
  • DrLact safety Score for 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) usage in lactation

Its active metabolite is Theophylline (see it).

Answer by DrLact: About 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) usage in lactation

An expert panel considers use of 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) to be acceptable during breastfeeding.[1] Maternal 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of theophylline. There is no need to avoid 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) products; however, keep maternal serum theophylline concentrations in the lower part of the therapeutic range and monitor the infant for signs of theophylline side effects. Infant serum theophylline concentrations can help to determine if signs of agitation are due to theophylline. Avoiding breastfeeding for 2 hours after intravenous or 4 hours after an immediate-release oral 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) product can decrease the dose received by the breastfed infant.

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) Side Effects in Breastfeeding

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1) intake of 200 mg every six hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by theophylline in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal theophylline ingestion.[3] Accumulation of theophylline in infant serum appears most likely in neonates and premature infants because they eliminate theophylline slowly.[2][5]

Synonyms of 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd with 1,2-ethanediamine (2:1)

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