Is Pyrizin Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Pyrizin? Is Pyrizin safe for nursing mother and child? Does Pyrizin extracts into breast milk? Does Pyrizin has any long term or short term side effects on infants? Can Pyrizin influence milk supply or can Pyrizin decrease milk supply in lactating mothers?

Pyrizin lactation summary

Pyrizin usage has low risk in breastfeeding

DrLact safety Score for Pyrizin is 3 out of 8 which is considered Low Risk as per our analyses.
A safety Score of 3 indicates that usage of Pyrizin may cause some minor side effects in breastfed baby.
Our study of different scientific research indicates that Pyrizin may cause moderate to no side effects in lactating mother.
Most of scientific studies and research papers declaring usage of Pyrizin low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
While using Pyrizin We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Pyrizin usage in lactation

Colorante azoico con efecto analgésico en la mucosa del tracto urinario. Uno de sus metabolitos es el paracetamol. Puede teñir las secreciones corporales de color anaranjado. Riesgo de metahemoglobinemia. A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna. Producto de farmacocinética poco estudiada y de eficacia limitada. Hasta conocer más datos sobre este fármaco, son preferibles alternativas conocidas más seguras, en especial en el periodo neonatal y en caso de prematuridad o déficit de glucosa-6PD.

Answer by DrLact: About Pyrizin usage in lactation

The safety of phenazopyridine is not established in infants or during breastfeeding. Because it can cause methemoglobinemia, sulfhemoglobinemia, and hemolytic anemia, it should be avoided while breastfeeding, especially with an infant under 1 month of age or with glucose-6-phosphate dehydrogenase (G6PD) deficiency.