Is Probenecid Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Probenecid? Is Probenecid safe for nursing mother and child? Does Probenecid extracts into breast milk? Does Probenecid has any long term or short term side effects on infants? Can Probenecid influence milk supply or can Probenecid decrease milk supply in lactating mothers?

It increases renal excretion of Uric acid and decreases elimination of many drug by the kidneys, among them beta-lactam antibiotics, with augmented plasma levels and effectiveness. Excretion into breast milk is clinically non-significant, with no problems observed among breastfed infants from treated mothers that could be attributed to Probenecid (reportedly, one case of self-limited diarrhea occurred in a child whose mother was taking a Cephalosporin together with Probenecid).

Limited information indicates that maternal doses of probenecid up to 2 grams daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. In animal studies, probenecid increased the breastmilk excretion of cimetidine, possible via an interaction with an active transport mechanism in the breast.[1] The implications of enhanced excretion of drugs given with probenecid for nursing mothers and their infants has not been studied; however, only a few drugs are known to undergo active transport into breastmilk.

A woman with mastitis received 3 days of intravenous cephalothin, followed by 16 days of probenecid 500 mg and cephalexin 500 mg 4 times daily for 16 days. Her infant developed green liquid stools, severe diarrhea, discomfort and crying. The authors judged the effects to be probably related to the cephalothin and cephalexin in milk rather than the probenecid.[2]