Is Valproic acid sodium salt (1:1) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Valproic acid sodium salt (1:1)? Is Valproic acid sodium salt (1:1) safe for nursing mother and child? Does Valproic acid sodium salt (1:1) extracts into breast milk? Does Valproic acid sodium salt (1:1) has any long term or short term side effects on infants? Can Valproic acid sodium salt (1:1) influence milk supply or can Valproic acid sodium salt (1:1) decrease milk supply in lactating mothers?
Valproic acid sodium salt (1:1) lactation summary
- DrLact safety Score for Valproic acid sodium salt (1:1) is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Valproic acid sodium salt (1:1) is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Valproic acid sodium salt (1:1) does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Valproic acid sodium salt (1:1) safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Valproic acid sodium salt (1:1) usage in lactation
It is excreted in breast milk in clinically non-significant amount without problems in the short or long term in infants whose mothers were treated. Plasma levels of these infants were undetectable or very low. Cognitive development did not suffer any alteration. An infant was presented with thrombocytopenic purpura and anemia who recovered after removing valproate in the mother. However, doubts were raised on whether it was instead a post-viral reaction that led to idiopathic thrombocytopenic purpura. The administration of valproic acid does not affect prolactin levels. The American Academy of Pediatrics rates it as usual compatible with breastfeeding medication.WHO List of Essential Medicines 2002: compatible with breastfeeding.