Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-OZU2FC70HY? Is UNII-OZU2FC70HY safe for nursing mother and child? Does UNII-OZU2FC70HY extracts into breast milk? Does UNII-OZU2FC70HY has any long term or short term side effects on infants? Can UNII-OZU2FC70HY influence milk supply or can UNII-OZU2FC70HY decrease milk supply in lactating mothers?

UNII-OZU2FC70HY lactation summary

UNII-OZU2FC70HY is safe in breastfeeding
  • DrLact safety Score for UNII-OZU2FC70HY is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of UNII-OZU2FC70HY is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that UNII-OZU2FC70HY does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of UNII-OZU2FC70HY safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-OZU2FC70HY usage in lactation

Herb commonly used from ancient times. Firm evidence is available on its effectiveness for treatment of depression, to the extent that it should be avoided a sudden stop of medication to prevent a rebound effect. It has been also topically used for the treatment of wounds, burns and eczema due to healing and antiseptical properties. Constituents are: Hypericin, Hyperforin and Quercetin. Antidepressant properties are attributed to Hypericin but mostly to Hyperforin. Quercetin is a flavonoid which is commonly found in many fruits and eatable vegetables. Hyperforin is excreted into breast milk in nil or clinically non-significant amount with not side-effects reported among breastfed infants from treated mothers, except for isolated and dubious cases of somnolence and colicky pain with spontaneous resolution with no medical intervention being required. Plasma levels in those infants were undetectable or close to the lower detectable point (0.1μg/L). Hypericin has not been detected in the breast milk. Quercetin levels found were as low as of few nanomols/L., and related to composition of fruits and vegetables of diet. It is most important to make sure that composition and amount of Hypericum contained in commercially available products is correct, do not take it without medical surveillance, avoid sudden stop and consider pharmacological interactions with many other medications.
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