Question

I am a breastfeeding mother and i want to know if it is safe to use Diatrizoate meglumine? Is Diatrizoate meglumine safe for nursing mother and child? Does Diatrizoate meglumine extracts into breast milk? Does Diatrizoate meglumine has any long term or short term side effects on infants? Can Diatrizoate meglumine influence milk supply or can Diatrizoate meglumine decrease milk supply in lactating mothers?

Diatrizoate meglumine lactation summary

Diatrizoate meglumine is safe in breastfeeding
  • DrLact safety Score for Diatrizoate meglumine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Diatrizoate meglumine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Diatrizoate meglumine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Diatrizoate meglumine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Diatrizoate meglumine usage in lactation

The X-ray contrast media that contain Amidotryzoic acid, Meglumine and Sodium have a content of Iodine from 47% to 62%.Amidotryzoate excretion into breast milk is nil (Fitzjohn, 1982) or in clinically non-significant amount (Texier, 1983: <0.1% of maternal dose) and there have been no problems in infants whose mothers were on this medication. The various Iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other, and some of them have shown no or minimal excretion in the breast milk. Given a low lipoid solubility of the iodinated contrast media, less than 1% of the dose administered to the mother has been found to in the milk.Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that would be swallowed by the infant.The maximum that is finally got by the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to an infant who undergoes a radiological contrast examination. Most Scientific Societies of Radiology have agreed that after a radiological iodinated contrast examination is not necessary a temporary weaning of the baby. American Academy of Pediatrics classifies it as usually compatible with breastfeeding medication.WHO List of Essential Medicines 2002 states it is compatible with breastfeeding.
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