Is Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI)? Is Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) safe for nursing mother and child? Does Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) extracts into breast milk? Does Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) has any long term or short term side effects on infants? Can Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) influence milk supply or can Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) decrease milk supply in lactating mothers?
Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) lactation summary
- DrLact safety Score for Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Theophylline, 8-chloro-, compd. with 10-(2-dimethylaminopropyl)phenothiazine (6CI) usage in lactation
1st-generation-antihistamine and phenothiazine-type drug with a strong sedative effect. At latest update relevant published data on excretion into breast milk were not found. It may decrease prolactin levels and interfere with milk production during the first few weeks after birth (Pontiroli 1981, Messinis 1985).Pharmacokinetic data (high volume of distribution and high plasma protein-binding capacity) would render it unlikely a significant passage into the breastmilk.In addition, a low oral bioavailability would hinder a further passage to infant’s plasma through the ingested breastmilk, except on premature infants and immediate neonatal period when there may be an increased intestinal permeability.There are doubts about any association with Sudden Infant Death Syndrome (SIDS) (Kahn 1982, Stanton 1983). It may be considered compatible with breastfeeding on isolated doses such as those used for pre-surgical medication or traveler's dizziness (WHO 2002). Avoid a repeated use as it may cause drowsiness in the infant.Avoid using it in the immediate neonatal period (first 4 to 6 weeks after birth) and in case of prematurity. If used, follow-up the infant for drowsiness and feeding issues. It is not recommended bed-sharing when taking this medication (UNICEF 2006, ABM 2008, Landa 2012, UNICEF 2013).