Question

I am a breastfeeding mother and i want to know if it is safe to use CR-604? Is CR-604 safe for nursing mother and child? Does CR-604 extracts into breast milk? Does CR-604 has any long term or short term side effects on infants? Can CR-604 influence milk supply or can CR-604 decrease milk supply in lactating mothers?

CR-604 lactation summary

CR-604 is unsafe in breastfeeding
  • DrLact safety Score for CR-604 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of CR-604 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that CR-604 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using CR-604 .
  • It is recommended to evaluate the advantage of not breastfeeding while using CR-604 Vs not using CR-604 And continue breastfeeding.
  • While using CR-604 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About CR-604 usage in lactation

Indometacin-precursor drug which is conjugated to proglumide that is a gastric protector. Proglumide may inhibit gastric secretory function by an antagonistic action on cholecystocinin, the latter has been found in the brain and related to development of maternal behaviour in mammals.
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