Is Oxitriptanum [INN-Latin] Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Oxitriptanum [INN-Latin]? Is Oxitriptanum [INN-Latin] safe for nursing mother and child? Does Oxitriptanum [INN-Latin] extracts into breast milk? Does Oxitriptanum [INN-Latin] has any long term or short term side effects on infants? Can Oxitriptanum [INN-Latin] influence milk supply or can Oxitriptanum [INN-Latin] decrease milk supply in lactating mothers?
Oxitriptanum [INN-Latin] lactation summary
![Oxitriptanum [INN-Latin] usage has low risk in breastfeeding](/images/breastfeeding/low-risk-in-breastfeeding.jpg "Oxitriptanum [INN-Latin] breastfeeding")
- DrLact safety Score for Oxitriptanum [INN-Latin] is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Oxitriptanum [INN-Latin] may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Oxitriptanum [INN-Latin] may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Oxitriptanum [INN-Latin] low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Oxitriptanum [INN-Latin] We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Oxitriptanum [INN-Latin] usage in lactation
Oxitriptan or 5-HTP is a metabolite of the natural amino acid L-Tryptophan, a component of proteins. In turn it is the immediate precursor of serotonin.It is abundantly found in the seeds of the African plant griffonia simplicifolia (Rondanelli 2012). It is used as an antidepressant, to treat fibromyalgia, neurological disorders, headaches, insomnia and obesity with controversy over the lack of evidence of its effetiveness (MedlinePlus 2016, Shaw 2002, Alt Med Rev 1998). Levels of 5-HTP and tryptophan decrease in the mother during childbirth, while they increase in cord blood (Carretti 2003). Like L-Tryptophan, its use has been associated with a serious epidemic of eosinophilia-myalgia syndrome with more than 1,500 cases and 37 deaths occurring in the 1990s, possibly caused by contaminated or poorly prepared batches of tryptophan (Medline Plus 2016, Klarskov 2003, Klarskov 1999, Michelson 1994). The FDA has not authorized its as a drug. Since the last update we have not found any published data on its excretion in breast milk. Its pharmacokinetic data (low molecular weight, low protein binding, low volume of distribution) make it likely that it would pass into breast milk in amounts which could be significant. It can increase prolactin levels (Lancranjan 1977). Due to the lack of evidence on its efficacy and the possibility of side effects, it is a drug that is non-essential during breastfeeding. If used, very moderate consumption is recommended and and it must come from a reliable source, given the poisonings that have previously occurred (Medline Plus 2016).