Is Busulfex Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Busulfex? Is Busulfex safe for nursing mother and child? Does Busulfex extracts into breast milk? Does Busulfex has any long term or short term side effects on infants? Can Busulfex influence milk supply or can Busulfex decrease milk supply in lactating mothers?
Busulfex lactation summary
- DrLact safety Score for Busulfex is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of Busulfex may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that Busulfex may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using Busulfex .
- Usage of Busulfex is in contradiction to breastfeeding hence if it is must to use Busulfex and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Busulfex usage in lactation
Drug is cleared from the body in 10 elimination half-lives. Resuming breastfeeding is likely safe after 24 hours of pumping-and-dumping.
Answer by DrLact: About Busulfex usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.[1] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence. Although minimal data are available to determine an appropriate period to withhold breastfeeding, the drug's terminal half-live of 2.5 hours suggests that withholding breastfeeding for at least 24 hours may be sufficient. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[3]
Busulfex Side Effects in Breastfeeding
Busulfex in a dosage of 4 mg/day for 5 weeks was taken for myeloid leukemia by one woman while breastfeeding. Weekly monitoring found no adverse effects on her infant's leukocyte count or hemoglobin.[3]
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