Question

I am a breastfeeding mother and i want to know if it is safe to use 5-21-03-00492 (Beilstein Handbook Reference)? Is 5-21-03-00492 (Beilstein Handbook Reference) safe for nursing mother and child? Does 5-21-03-00492 (Beilstein Handbook Reference) extracts into breast milk? Does 5-21-03-00492 (Beilstein Handbook Reference) has any long term or short term side effects on infants? Can 5-21-03-00492 (Beilstein Handbook Reference) influence milk supply or can 5-21-03-00492 (Beilstein Handbook Reference) decrease milk supply in lactating mothers?

5-21-03-00492 (Beilstein Handbook Reference) lactation summary

5-21-03-00492 (Beilstein Handbook Reference) usage has low risk in breastfeeding
  • DrLact safety Score for 5-21-03-00492 (Beilstein Handbook Reference) is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of 5-21-03-00492 (Beilstein Handbook Reference) may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that 5-21-03-00492 (Beilstein Handbook Reference) may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of 5-21-03-00492 (Beilstein Handbook Reference) low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using 5-21-03-00492 (Beilstein Handbook Reference) We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 5-21-03-00492 (Beilstein Handbook Reference) usage in lactation

It is a first generation antihistaminic and ethanolamine drug with a markedly sedative and antimuscarinic effect (may inhibit lactation). When associated to phenylephrine it is used for nasal congestion relief. Use a minimal dose. Avoid a long-term use.

Answer by DrLact: About 5-21-03-00492 (Beilstein Handbook Reference) usage in lactation

Small occasional doses of 5-21-03-00492 (Beilstein Handbook Reference) are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

5-21-03-00492 (Beilstein Handbook Reference) Side Effects in Breastfeeding

There are no reports of infants breastfed during maternal therapy with 5-21-03-00492 (Beilstein Handbook Reference). In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

5-21-03-00492 (Beilstein Handbook Reference) Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of 5-21-03-00492 (Beilstein Handbook Reference) have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.